Ubiquilin Proteins are Critical Adaptors that Regulate Proteostasis
نویسنده
چکیده
Our study ‘The STI and UBA Domains of UBQLN1 are Critical Determinants of Substrate Interaction and Proteostasis’, highlights the role of individual domains of UBQLN1 in stabilizing substrates (BCLb, IGF1R and ESYT2). Research on UBQLN1 has mostly been focused on its role in protein quality control and degradation of substrates that it binds to. However, we have identified substrates of UBQLN1 that are stabilized as a result of their association. We demonstrated that fate of substrates that UBQLN1 binds to is interaction-domain specific. The STI and UBA domains of UBQLN1 interact with BCLb, IGF1R and ESYT2 and stabilize these proteins while the stability of PSMD4 and BAG6, which interact with the UBL domain of UBQLN1 were not altered.
منابع مشابه
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تاریخ انتشار 2017